Biophotonics | Life Sciences | Environmental Analytics
As part of its applied research in optical technologies, the HOT works on several focal topics from the fields of biophotonics, life sciences, and environmental analytics.
Currently, our work focuses on
- microplastics: online-detection in flowing drinking water
- microalgae: carotenoid analysis and effects of environmental stress
- bacteria: non-invasive analysis of relative relatedness („in vivo phylogeny“)
- biofilms: non-invasive observation over time, species identification, and 3D structure
- human skin: optical analytics (dermatoscopy, melanoma thickness, quantification of carotenoids, vitamin D synthesis)
- inner ear: non-invasive optical diagnostics
- proteins: functional analysis
For this, we are working on new or improved experimental and data analysis methods
- multivariate and cluster analysis: for the discrimination and grouping of spectra
- Raman Resonance Profiles: high-resolution resonance profiles, molecular identfication, and tunable Rayleigh-filters
- simulation and image processing: Raman spectra, OCT, opto acoustics, photophysics and -chemistry
Our most often used optical methods are
- confocal Raman microscopy (spatial resolution at cell level; molecular information)
- resonance Raman spectroscopy (molecular and molecular group-information)
- absorption- and transmission spectroscopy
- holographic microscopy
- opto acoustics
- optical coherent tomography (OCT)
and the combination of these methods.
Biophotonics and Analytics
OPTIMUS -Raman spectroscopy of microplastics, microbes, and trace elements
Prof. Dr. Bernhard Roth
Dr. Ann-Kathrin Kniggendorf
1.3.2016 - 28.2.2019
Bundesministerium für Bildung und Forschung (BMBF)
online detection of contaminated microplastics in streaming drinking water with Raman spectroscopy for the BMBF joint project OPTIMUS.
Smartphone based optical point of care tests
Dr. Maik Rahlves, Dipl.-Kffr. Rima Rifai, Dr. Johanna Walter
Bundesministerium für Wirtschaft und Energie (BMWi) und Europäischer Sozialfond (ESF)
Developing of Smartphone based point of care tests using aptamer functionalized surface plasmon (SPR) sensors.
Determination of melanoma thickness via optoacoustics and optical coherence tomography (OCT)
Prof. Dr. Bernhard Roth, Prof. Dr. Uwe Morgner, Dr. Maik Rahlves, Dr. Merve Wollweber
09.2013 - 01.2017
Development of a method for the preoperative determination of the thickness of melanoma suspicious skin lesions.
Dr. Chandrajit Basu
Research on a digital system for dermatoscopy with enhanced diagnostic capabilities for automated whole-body-cancer-screening.